Biosciences: Books

Chronobiology and Chronomedicine

Circadian rhythms have been shown to be ubiquitous and critically important in the experimental laboratory, accounting for the difference between life and death in response to identical stimulus. The partly endogenous nature of circadian rhythms has been well documented and methods for their characterisation have been developed enabling the cellular and molecular mechanisms to be understood. Chronobiology and Chronomedicine aims to provide a review of these mechanisms underlying circadian rhythms and illustrate the role of the brain's suprachiasmatic nuclei in the 'pace-making' process and the effects caused by 'clock genes' present in almost all cells. Beyond the mechanisms involved, the book discusses the relationship between body systems, disease, and proper circadian function; in particular, how disruption of the circadian rhythm is associated with ill health and disease status from observations made at the organismic level. (Provided by Publisher.)

Basic Life Science Methods

Basic Life Science Methods: A Laboratory Manual for Students and Researchers presents forty of the most executed life science assays. The authors use a consistent structure to cover the preparation, execution and analysis of data from each method. Assays include estimation of cholesterol fractions, C-Reactive Protein, Genomic DNA isolation, Agarose Gel Electrophoresis, RT-PCR, DNA solution preparation, how to design primers, and enzyme-linked immunosorbent assay (ELISA). This book provides a complete reference containing step-by-step instructions on how to run life science assays. Laboratory staff can also benefit of the book as a training resource (Provided by Publisher).

The Age of Mammals: Nature, Development, & Palaeontology in the Long Nineteenth Century

When people today hear "paleontology," they immediately think of dinosaurs. But for much of the history of the discipline, dramatic demonstrations of the history of life focused on the developmental history of mammals. The Age of Mammals examines how nineteenth-century scholars, writers, artists, and public audiences understood the animals they regarded as being at the summit of life. For them, mammals were crucial for understanding the formation (and possibly the future) of the natural world. Yet, as Chris Manias reveals, this combined with more troubling notions: that seemingly promising creatures had been swept aside in the "struggle for life," or that modern biodiversity was impoverished compared to previous eras. Why some prehistoric creatures, such as the saber-toothed cat and ground sloth, had become extinct, while others seemed to have been the ancestors of familiar animals like elephants and horses, was a question loaded with cultural assumptions, ambiguity, and trepidation. How humans related to deep developmental processes, and whether "the Age of Man" was qualitatively different from the Age of Mammals, led to reflections on humanity's place within the natural world. With this book, Manias considers the cultural resonance of mammal paleontology from an international perspective--how reconstructions of the deep past of fossil mammals across the world conditioned new understandings of nature and the current environment (Provided by Publisher).

This title was acquired through the Library's Order a Book service.

Machine Learning in Biological Sciences

This book gives an overview of applications of Machine Learning (ML) in diverse fields of biological sciences, including healthcare, animal sciences, agriculture, and plant sciences. Machine learning has major applications in process modelling, computer vision, signal processing, speech recognition, and language understanding and processing and life, and health sciences. It is increasingly used in understanding DNA patterns and in precision medicine. This book is divided into eight major sections, each containing chapters that describe the application of ML in a certain field. The book begins by giving an introduction to ML and the various ML methods. It then covers interesting and timely aspects such as applications in genetics, cell biology, the study of plant-pathogen interactions, and animal behavior. The book discusses computational methods for toxicity prediction of environmental chemicals and drugs, which forms a major domain of research in the field of biology.  It is of relevance to post-graduate students and researchers interested in exploring the interdisciplinary areas of use of machine learning and deep learning in life sciences (Provided by Publisher).

Mass Spectrometry of Glycoproteins : Methods and Protocols

This volume presents methods used for the analysis of glycoproteins at different levels—intact, subunit, glycopeptide, and monosaccharide, and discusses and solves most analytical challenges that a scientist working on glycoproteins may come across. The chapters in this book cover topics such as the role of glycosylation on the properties of therapeutic glycoproteins; different analytical methods to characterize glycosylation, from the intact proteins to the glycan level, for both N-linked and O-linked glycoproteins; mass spectrometry imaging methodology for glycosylation analysis in tissues; approaches to characterizing glycosylation on cultured cells; and the use of cloud computing to deploy mass spectrometry data analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. (Provided by Publisher.)

This title was acquired by the Library's Order a Book service.